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M94A3143.TXT
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1994-10-25
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Document 3143
DOCN M94A3143
TI Demographics and survival in urban adults with HIV disease.
DT 9412
AU Chaisson RE; Keruly J; Moore RD; Johns Hopkins Univ., Baltimore, MD.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):144 (abstract no. PB0001). Unique
Identifier : AIDSLINE ICA10/94369432
AB OBJECTIVE: To compare survival patterns in a demographically mixed
population of patients with HIV disease from an urban area. METHODS:
Patients registered in an urban HIV Clinic were followed observationally
for a mean of 15 months (median 12) from entry. Survival was analyzed by
selected demographic factors and CD4 counts. Cox proportional hazards
modelling was used to identify predictors of death. RESULTS: The cohort
consists of 895 patients. Patients are 69% male, 31% female, 78% black,
20% gay-bisexual, 49% IDU, and 31% heterosexual risk. Entry CD4 counts
were < 50 in 19%, 50-200 in 18%, 201-500 in 36%, and > 500 in 28%.
During followup, 165 patients (18%) died. Mortality was 50% for CD4 <
50, 34% for CD4 50-200, and 5% for CD4 > 200 (p < .0001). For patients
with entry CD4 < 200, median survival was 649 days for men and 621 days
for women. The hazard of death was not increased for women (RH .96) or
IDUs (RH 1.2). Entry CD4 < 50 was strongly associated with death (RH
9.1, p < .0001), as was entry CD4 50-200 (RH 2.2, p < .0001).
CONCLUSION: In this heterogeneous urban cohort, demographic factors were
not associated with death from HIV. CD4 counts were the strongest
predictors of survival and have similar utility in men and women.
DE Adult Baltimore/EPIDEMIOLOGY Bisexuality Blacks Cohort Studies
Comparative Study Demography Female Homosexuality Human HIV
Infections/IMMUNOLOGY/*MORTALITY Male Prognosis Proportional Hazards
Models Risk Factors Sex Behavior Sex Factors Substance Abuse,
Intravenous Survival Rate T4 Lymphocytes/IMMUNOLOGY Urban
Population/*STATISTICS & NUMER DATA MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).